Earth-1218 is the reality designated to our universe, it was first designated in the letters page of New Exiles #3 and is numbered after the editor of the book, Jordan D. White. While it is possible for characters to reference Earth-1218 such as Deadpool, Gwenpool and She-Hulk our reality generally plays by the same rules as our actual reality.
In this reality, all characters from other realities are considered as fictional creations currently owned by Marvel Comics. It's stated in-universe that superpowered individuals would automatically lose their abilities upon entering this reality due to the rules of this reality being too strict to allow for superheroes and god-like beings.
While characters have occasionally showed up in an Earth similar to ours, these are viewed as variations due to the aforementioned loss of powers heroes would experience failing to occur. The most notable moment of a character crossing into an Earth similar to ours would be in the finale of Spider-man: The Animated Series which featured a version of Stan Lee who is notable for his contributions to the Marvel lineage.